Enamelon Advantage

Discover the Enamelon® Advantage

Enamelon® is the new standard of caring, a safe and effective alternative to 5000 ppm F toothpastes and remineralizing pastes, to help prevent caries, gingivitis and treat sensitivity. Enamelon utilizes the remineralizing technology of Amorphous Calcium Phosphate (ACP) and contains Ultramulsion® and mucoadhesive co-polymers, a unique combination that increases substantivity and creates a great mouth-feel.

Enamelon® Preventive Treatment Gel provides 3x greater reduction of enamel solubility with twice as much fluoride uptake as 5000 ppm F toothpastes.

Enamelon® Preventive Treatment Gel contains 970 ppm fluoride ion, yet this patent-pending formula utilizes calcium and phosphate ions to uniquely deliver more fluoride uptake to teeth. Additionally, this is the first formula to combine the protective properties of the stannous ion with the remineralizing potential of ACP technology. The unique saliva-stimulating formula provides an enhanced ability to form loosely bound calcium fluoride reservoirs. These reservoirs provide a vital source of remineralizing ions in the presence of an acid challenge. The release of these ions helps to promote remineralization and inhibit demineralization.

The result is more protection with less fluoride exposure!

3x Greater reduction of enamel solubility

Enamel Solubility Reduction FDA Method #33
Negative Control (Water) recorded a -5.45% Enamel Solubility Reduction

In-vitro testing shows that Enamelon® reduces the solubility of enamel, preventing demineralization of the tooth surface when exposed to acids. Enamelon Preventive Treatment Gel decreases enamel solubility by 56.91% compared to 18.78% with 5000 ppm fluoride paste, providing 3x greater protection against acid challenges.

More protection with less fluoride

Enamel Fluoride Uptake (ppm F) FDA Method #40

Enamelon® provides over 2x more beneficial fluoride with only one-fifth the amount contained in 5000 ppm fluoride toothpastes. You safely can dispense Enamelon® Preventive Treatment Gel to your entire patient population for daily long-term use.

Enamelon® Toothpaste

More protection, easy compliance
Enamel Fluoride Uptake (ppm F) FDA Method #40

More Fluoride Protection

Enamelon® provides over 2x more fluoride uptake, due to the patent-pending fluoride, calcium and phosphate formula, than over-the-counter (OTC) toothpastes

"Dispense with confidence!

Age – ADA recommendations*

Fluoride toothpaste is intended to maximize the caries preventive benefits of fluoride use in young children while reducing the risk of developing fluorosis.

  • “Smear” of toothpaste from eruption of first tooth up to age 3*
  • “Pea-sized” amount of toothpaste for children ages 3 to 6*
  • “Strip-size” from age 6 and older

Smear amount (0.125 g)

Pea-sized amount (0.25 g)

Safe for daily use - for all ages. Dose based on age.


The non-abrasive gel and low-abrasive toothpaste are formulated with Ultramulsion®, a patented saliva-soluble coating that moisturizes and soothes oral soft tissues and helps to prevent staining. Enamelon® does not contain Sodium Lauryl Sulfate (SLS) commonly found in 5000 ppm F toothpastes and 1100 - 1150 ppm F toothpastes. Refreshing mint flavors are enhanced with spilanthes, a natural herb that boosts salivary flow to help protect dental soft and hard tissues.

Controlled Dispensing

Studies suggest that caregivers commonly apply up to twice the amount of toothpaste recommended. Enamelon offers reduced-sized orifices so patients - and parents - easily can control dispensing/dosage.